IntraLase Announces First Use of FS Laser for Advanced Corneal Transplant Surgery; Precise Femtosecond Laser Technology Allows Surgeons to Create Optimally Shaped Incisions for Biomechanical Advantage

IRVINE, Calif.--(BUSINESS WIRE)--Jan. 26, 2006--IntraLase Corp. (Nasdaq:ILSE) today announced the first corneal transplant cases using the IntraLase(R) FS laser have been successfully performed in patients, marking the first major technology advancement in corneal transplant surgery in more than five years. The use of IntraLase's ultra-fast laser to create a contoured, full-thickness corneal resection in preparation for corneal transplant has the potential to make corneal transplantation a safer, more precise procedure as the all-laser approach gains favor among transplant surgeons. Full global launch of this new therapeutic application is expected in Fall 2006.

Three of the country's leading ophthalmic institutes, Bascom Palmer Eye Institute at the University of Miami, Corneal Research Foundation of America of Indianapolis and the University of California Irvine, Department of Ophthalmology, are among the first in the country to adopt all-laser corneal transplant surgery. They've affirmed IntraLase's ability to improve the surgery, considered the last resort for patients facing blindness resulting from severe corneal disease.

The IntraLase FS laser is the first femtosecond laser cleared for use in a variety of refractive and corneal surgeries including LASIK, and intrastromal incisions used with ring implants, lamellar keratoplasty, penetrating keratoplasty, and for the preparation of the donor tissue used in corneal transplants. The IntraLase FS laser has demonstrated its superior capability in creating corneal incisions with micron-level accuracy unmatched by hand-held or mechanical blades.

"The natural progression of our laser technology is to provide corneal surgeons with the ability to shape the full-thickness resection used in corneal transplants," said Robert J. Palmisano, president and CEO of IntraLase. "With minor enhancements, our laser is capable of creating optimal incisional patterns for corneal transplants. Instead of the straight vertical cut performed in traditional full-thickness keratoplasty, the FS laser is programmed to create a stepped-edged incision that may enhance the sealing and stability of the transplanted tissue and allow for faster healing."

"The early results are excellent," noted Francis Price, M.D., director of the Corneal Research Foundation of America and Price Vision Group and first to perform corneal transplant surgery with the IntraLase laser. "One of the patients had traditional full-thickness corneal transplant surgery three years ago on one eye. The day after her laser-assisted transplant surgery, she reported seeing better in the laser-treated eye. While the long-term outcome remains to be seen, the early results are very encouraging."

In 2003, a scalpel was used to create modified-shaped tissue, resembling a top hat, during penetrating keratoplasty surgery. "The shaped top hat configuration never achieved widespread success because of the difficulty in manually creating the incision. The precision and safety of the IntraLase laser inspires the surgeon to perform the top hat incision with confidence," said William Culbertson, M.D., professor of ophthalmology and corneal surgeon at Bascom Palmer Eye Institute. "The overlapping wound edge seals better biomechanically requiring less suture tension than a traditional straight-edged incision. The potential result would be enhanced wound strength, less astigmatism and accelerated recovery of vision. We feel this is a huge step forward in the rehabilitation of vision for these patients."

Latest findings on this and all other FS laser indications will be presented at this year's American Society of Cataract and Refractive Surgery (ASCRS) held March 18-22, 2006 in San Francisco.

About IntraLase Corp.
IntraLase designs, develops, and manufactures an ultra-fast laser that is revolutionizing refractive and corneal surgery by creating safe and more precise corneal incisions. Delivering on the promise of ophthalmic laser technology, the IntraLase FS laser, related software, and disposable devices replace the hand-held microkeratome blade used during LASIK surgery. The unsurpassed accuracy of IntraLase's computer-controlled femtosecond laser has been shown to improve safety profiles and visual outcomes when used during LASIK. Additionally, the IntraLase FS laser creates precision-designed intracorneal incisions that when combined can be used during lamellar and penetrating keratoplasties and intrastromal ring implantation. IntraLase is presently in the process of commercializing applications of its technology in the treatment of corneal diseases that require corneal transplant surgery. The company's proprietary laser and disposable patient interfaces are presently marketed throughout the United States and 26 other countries. IntraLase is headquartered and manufactures its products in Irvine, California. For additional information, visit the company's web site: www.intralase.com.